Why do our bodies wear out as we grow old? Meet Charles Mobbs, a scientist at Mount Sinai School of Medicine in New York. By trying to answer this mysterious question, he and his team have found what could be a way to do something long thought impossible: reverse kidney damage caused by diabetes.

The following is a short statement by Dr. Charles Mobbs:

“Diabetic complications, including kidney failure, develop progressively and become apparently irreversible, even with complete correction of blood glucose. However, based on our studies of the basic mechanisms driving diabetic complications, we hypothesized that decreasing glucose metabolism as well as blood glucose levels would allow reversal of diabetic complications. We had previously shown that a particular chemical known as a ketone, which is used as fuel for the brain during nutritional deprivation, could block glucose metabolism. Ketone levels in the blood can also be produced by the low-carbohydrate low-protein ketogenic diet, which is used to treat epilepsy in people.

We therefore tested if the ketogenic diet would reverse diabetic kidney disease. To do this we studied mice with either Type 1 or Type 2 diabetes, waited until they showed evidence of kidney disease (protein in the urine), then placed them on the ketogenic diet. Within days their blood glucose levels were completely corrected. After 8 weeks urine protein was completely corrected. The diet also corrected many molecular abnormalities caused by diabetic kidney disease. These studies show for the first time that diabetic kidney failure can be reversed by a relatively simple dietary manipulation. However, more studies on the safety and efficacy of this diet are required before the diet can be recommended for patients with diabetic kidney failure.”

This video is based on:

Reversal of Diabetic Nephropathy by a Ketogenic Diet, a paper published by Charles Mobbs and colleagues in the online journal PLoS ONE.

 

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